A new crystal form of human vascular adhesion protein 1

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Vascular Adhesion Protein 1 in the Eye

Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1), a dual-function molecule with adhesive and enzymatic properties, is expressed on the surface of vascular endothelial cells of mammals. It also exists as a soluble form (sVAP-1), which is implicated in oxidative stress via its enzymatic activity and can be a prognostic biomarker. Recent evidence suggests that VAP-1 i...

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Vascular adhesion protein-1 (VAP-1) is an amine oxidase and adhesion receptor that is expressed by endothelium in the human liver. The hepatic sinusoids are perfused by blood at low flow rates, and sinusoidal endothelium lacks selectin expression and has low levels of CD31, suggesting that VAP-1 may play a specific role in lymphocyte recruitment to the liver. In support of this we now report th...

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ژورنال

عنوان ژورنال: Acta Crystallographica Section F Structural Biology and Crystallization Communications

سال: 2010

ISSN: 1744-3091

DOI: 10.1107/s1744309110041515